منابع مشابه
Genome instability: McClintock revisited
Recent studies in yeast have shed light on the molecular mechanisms by which telomere dysfunction leads to chromosome fusions. Furthermore, examination of the consequences of telomerase loss in mice suggests that only a few critically short telomeres may be sufficient to promote genomic instability.
متن کاملBarbara McClintock on Defining the Unstable Genome.
It is with this prescient statement that Barbara McClintock began the discussion of her classic 1953 GENETICS article describing how so-called “extragenic” components, now known as transposons, could alter the function of nearby genes. Precisely 30 years later she would be the sole winner of the Nobel Prize in Physiology or Medicine for her scrupulous studies of unexpected phenotypic changes sh...
متن کاملGenome Instability
Maintaining genomic stability in the face of replication and recombination requires a huge variety of different damage response proteins. A cell’s ability to decide when and where to deploy this DNA repair kit is critical to prevent tumor development. This issue’s Select highlights recent studies that help to explain how these difficult decisions are made and reveals that some surprising cellul...
متن کاملGenome Instability
To whet your appetite for the special focus in next issue’s Leading Edge on Genomic Instability, we take a look at what’s new in the field of DNA repair. Ranging from network analyses of the proteins involved in mutagenic DNA repair to examination of single molecules taking part in homologous recombination, this Select probes the inner workings of a process that can wreak havoc during carcinoge...
متن کاملCommentary: Functional Ankle Instability Revisited.
Chronic ankle instability is a clinical problem frequently seen in athletes. Various complicated mechanical and neuromuscular factors seem to be involved in chronic ankle instability. The purpose of this special communication is to revisit the concept of functional ankle instability and to discuss its clinical relevance. The 2 hypothesized causes of chronic ankle instability have been labelled ...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2001
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(01)00573-5